Microorganisms for BPA degradation with inulinase activity

Bisphenol A (BPA) is a xenobiotic, widely used as a plastic precursor, with a growing presence in the environment, diet and cosmetics, among others. The pervasiveness of this substance, along with its analogues and derivatives, has been linked to the development of endocrine and metabolic diseases, such as obesity, diabetes, metabolic syndrome, fatty liver disease, hyperactivity disorders or cancer.

Researchers at the University of Granada have identified a Bacillus sp. strain from the human gut microbiota, with the ability of degradation and removal of bisphenol A.

Whole Genome Sequence analysis of these bacteria, with inulinase activity, revealed the presence of a complete enzymatic, molecular and genetic arsenal, specific for endocrine disruptors degradation, such as BPA. They are capable of tolerating and metabolizing it, while using it as a carbon source.

This activity evidences this strain’s potential, either alone or in combination with others, for the production of probiotic foods and/or plant probiotics for its addition to phytosanitary compositions, taking advantage of the ability to modulate those xenobiotics, relieving its endocrine pathogenesis and/or its use in bioremediation.

ADVANTAGES AND BENEFITS:

• Bisphenol A degradation.These bacteria are capable of metabolizing endocrine disruptors, such as bisphenol A, which is useful to its removal.
• Multitude of applications. Bisphenol A degradation can be useful in a wide range of areas:
  • Nutrition. Development of functional foods for human or veterinary use.
  • Human health. Modulation of endocrine pathogenesis caused by BPA.
  • Agriculture. Development of phytosanitary compositions for plants.
  • Bioremediation. Focused on the removal of contaminants from water.
• High efficiency removal. Bacillus sp. AM1 strain can remove 84% of BPA in 72 hours.
• Safe microorganisms. These bacteria has been isolated from the human microbiota, so it will very possibly meet the safety criteria and be granted QPS status (Qualified Presumption of Safety).

Current development status

Laboratory prototypes

Desired business relationship

Patent licensing

Applications

Human health

Nutrition

Agriculture

Bioremediation