The research group BIONANODEN «Dendritic Nanosystems for Biomedical Applications» oftheUniversityofAlcalápresents the procedure for obtaining and using of magnetic nanoparticles stabilized with cationic carbosilane dendritic systems. These nanoparticles interact with microorganism and nucleic acids for their removal or extraction.The group seeks to reach licensing agreements, collaboration agreements or commercial agreements with technical assistance, with enterprises from the food industry, cosmetic, biotechnology, Biomedicine or pharmaceutical sector.
DESCRIPTION AND SPECIAL FEATURES
The present inventiondevelops magnetic nanoparticles (MNPs) thancontain on the surfacecationic carbosilane dendritic molecules. These molecules are multifunctional and allow increasingthe number of functions on the NPs surface. Moreover, due to their structure, these groups areavailable for interaction with the environment, since are located apart from the NP surface.The cationic groups of dendritic MNPs interact with microorganisms as bacteria, which cell wallpresent negative domains, and with phosphate groups of nucleic acid chains (DNA, RNA, etc.).
Onthe otherhand, the magnetic properties of the MNPs favour their use due to the fact that theapplication of an external magnetic field removes the NPs from any suspension.The combination of the above characteristics have been exploited to remove bacteria and nucleicacids from aqueous suspensions, by mixing the suspension containing bacteria or nucleic acidswith the MNPs and then applying a magnetic field (even with a simple neodymium magnet).
These MNPs covered with dendritic carbosilane molecules are useful forwater purification,microorganism or nucleic acid detection or for their removal.
INNOVATIVE ASPECTS
Magnetic nanoparticles with carbosilane dendrimers that:
-Respond predictably in solution-Interact with bacteria cell walls
-Interact with nucleicacids-Nothing similar has been found in patentdatabases
-Dendrimersaremultivalentsystemsthatallowtheincorporationofmultiplefunctionalitieson thenanoparticles surface.
-The dendritic systems favour the separation of the functional groups from nanoparticle surface.
-The cationic charge favours the interaction with bacteria membranes and nucleic acids.-
- The magnetic properties of the nanoparticles allow their extraction from any suspension.
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